Microglia regulate GABAergic neurogenesis in prenatal human brain through IGF1.

ABSTRACT: GABAergic neurons are essential cellular components of neural circuits. Their abundance and diversity have increased significantly in the human brain, contributing to the expanded cognitive capacity of humans¹. However, the developmental mechanism underlying the extended production of GABAergic neurons in the human brain remains elusive. Here we uncovered the microglial regulation of the sustained proliferation of GABAergic progenitors and neuroblasts in the human medial ganglionic eminence (hMGE). We showed that microglia are preferentially distributed in the proliferating zone and identified insulin-like growth factor 1 (IGF1) and its receptor IGR1R as the predicted top ligand-receptor pair underlying microglia-progenitor communication in the prenatal hMGE. Using our newly dev

SUBMITTER: Yu D 

PROVIDER: S-EPMC12527950 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature