Development of Primary Colon and Duodenal Tumor Cultures from the Apc-mutant Pirc Rat for Screening Preventive Agents.

ABSTRACT: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality, with genetic, epigenetic, and immune-dependent mechanisms contributing to disease pathogenesis. Preventive strategies are especially important for individuals with hereditary syndromes such as familial adenomatous polyposis (FAP), in which Adenomatous Polyposis Coli (APC) mutations drive early tumor formation. The polyposis in rat colon (Pirc) model, harboring an Apc mutation, faithfully recapitulates the development of adenomatous polyps, a precursor stage of CRC, in both the colon and duodenum. Here, we report the generation and characterization of primary cell cultures derived from 30 colonic and duodenal adenomas (benign tumors) from Pirc rats. These Pirc colon adenoma and duodenal adenoma

SUBMITTER: Muhsin A 

PROVIDER: S-EPMC12527970 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature