Distinct microbial and metabolic shifts characterize acute coronary syndrome and recovery.

ABSTRACT: Early identification of patients at risk of acute coronary syndrome (ACS) remains a major unmet need, particularly among those with stable coronary artery disease (sCAD), where timely intervention could markedly improve outcomes. The gut microbiota has been implicated in coronary artery disease (CAD), but its ability to distinguish ACS from sCAD is not well defined. Here, we performed cross-sectional multi-omics profiling of fecal microbiota and plasma metabolites in 548 individuals, including participants with normal coronary arteries (N = 175), primary sCAD (N = 161), and ACS (N = 212). To assess whether disease-associated changes resolve with treatment, we further analyzed an independent cohort of ACS patients (N = 52) who transitioned to sCAD following stand

SUBMITTER: Xu J 

PROVIDER: S-EPMC12528003 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature