Oxymatrine inhibited the progression of renal cell carcinoma by increasing TOR1AIP1 expression.

ABSTRACT:

Aims

The extract of Radix sophorae tonkinensis, known as oxymatrine (OMT), demonstrates anticancer properties. This investigation explored the influence of oxymatrine on renal cell carcinoma (RCC) and elucidated the associated molecular mechanisms, both in vitro and in vivo.

Methods

RNA-seq was used to evaluate target genes regulated by OMT. The potential target gene TOR1AIP1 was identified, and the expression of TOR1AIP1 was analyzed in RCC cell lines (Caki-1 and 786-O cells) after treatment with OMT. Further functional assays, including in vitro proliferation, migration, and invasion experiments, were performed. Additionally, overexpression experiments were used to confirm the role of TOR1AIP1 in RCC. In vivo assays using a nude mouse model were

SUBMITTER: Yan X 

PROVIDER: S-EPMC12528049 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature