The effect of treatment with a non-ionic surfactant vesicular formulation of sodium stibogluconate on host immune responses and serum metabolites in a murine model of <i>Leishmania donovani</i>.

ABSTRACT:

Introduction

Visceral leishmaniasis (VL), caused by Leishmania donovani, is associated with parasite-induced immunological and physiological changes that ensure the survival of amastigotes within the host. Both the parasite and the host have nutritional requirements, and for auxotrophic Leishmania, dependence on the host to supply specific growth requirements is essential. This highlights an intricate link between host immunity and metabolism during VL. This study explores the interplay between the host metabolome and immune responses pre- and post-infection and treatment, aiming to identify early metabolite markers of therapeutic success against Leishmania.

Methods

BALB/c mice infected with L. donovani were divided into cured and non-cured groups

SUBMITTER: Aruleba RT 

PROVIDER: S-EPMC12528065 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature