Patterns of restricted TCR usage following SARS-CoV-2 vaccination and severe disease.

ABSTRACT:

Introduction

T cells influence COVID-19 severity and establish long-lasting immune memory in response to vaccination and infection. The diversity of the T cell repertoire, and complexity of T cell epitope recognition, make it challenging to define protective epitope-specific T cells. In this study, we created a highly specific TCR meta-database to identify T cell epitopes from the nearly complete SARS-CoV-2 proteome and determine whether vaccination with mRNA vaccines influenced the TCR repertoire.

Methods

Using this meta-database, we analyzed immunosequencing data of genomic DNA to define the variable region of T cell receptor (TCR) b chain (TCRB) sequences among participants in a longitudinal COVID-19 cohort study. The TCR repertoire was compared between participants who w

SUBMITTER: Parsons E 

PROVIDER: S-EPMC12528067 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature