Dual roles of <i>in situ</i> generated HSP70 in antigen delivery and immunoregulation.

ABSTRACT:

Introduction

Extracellular release of inducible HSP70 spurred interests to explore its potential interactions with innate immune systems. Both pro- and anti-inflammatory roles have been reported though the immunostimulatory roles were largely disputed due to the likely use of contaminated HSP70. The anti-inflammatory roles inspired the exploration of HSP70 to treat autoimmune diseases by suppressing pathological inflammatory responses. Besides immunomodulation, HSP70 has been explored as tumor vaccine carriers to elicit cytotoxic T lymphocyte responses due to its ability to deliver bound peptides to MHC I presentation pathway. With increasing understanding of the potential use of ex vivo prepared HSP70 in vaccination and therapy, the functions and potential applications of in si

SUBMITTER: Kang X 

PROVIDER: S-EPMC12528137 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature