Photodynamic inactivation of <i>Staphylococcus aureus</i> with rose bengal reduces superantigen activity.

ABSTRACT: Atopic dermatitis (AD) is a chronic inflammatory skin disorder marked by barrier dysfunction and immune dysregulation. Colonization of lesional skin by Staphylococcus aureus, present in up to 80-100% of cases, exacerbates inflammation, in part through production of superantigenic toxins. While standard treatments such as topical corticosteroids, antibiotics, and antiseptic baths are widely used, their outcomes remain variable and often inadequate, highlighting the need for alternative strategies that minimize adverse effects and resistance development. In this study, we evaluated antimicrobial photodynamic inactivation (aPDI) using rose bengal (RB), a photosensitizer activated by visible light, as a potential approach to reduce S. aureus colonization and virulence. Across

SUBMITTER: Ogonowska P 

PROVIDER: S-EPMC12528143 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature