Gut jet lag: how circadian rhythm disruption undermines the Chrono-Microbiota-Motility axis and induces functional constipation.

ABSTRACT: Functional constipation (FC) is a highly prevalent gastrointestinal disorder globally. Its complex and multidimensional pathophysiological mechanisms and the limitations of conventional treatments highlight the urgent need to explore new theoretical frameworks. Chronobiological research reveals that the circadian rhythm system plays a central role in maintaining physiological homeostasis, and rhythm disruption caused by modern lifestyles is becoming a common driving factor for various chronic diseases. The gut microbiota, as a key regulator of host physiology, its intrinsic rhythmicity and synchronization with the host's biological clock are crucial for gut health. This review systematically integrates cross-disciplinary evidence from chronobiology, microbiology, and gastrointestinal motil

SUBMITTER: Li J 

PROVIDER: S-EPMC12528175 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature