Genetic and serum biomarkers of NSAID hypersensitivity reactions.

ABSTRACT:

Background

Hypersensitivity reactions (HRs) to non-steroidal anti-inflammatory drugs (NSAIDs) constitute a significant clinical concern due to their frequency and possible severity. These reactions may involve specific immunological pathways, including activation of the high-affinity IgE receptor, or non-immunological mechanisms that result in similar clinical manifestations. Additionally, vitamin D plays an important role in the regulation of the immune response and therefore may be relevant to the development or progression of HRs to NSAIDs.

Methods

To identify new single nucleotide variants (SNVs) associated with HRs, we analyzed the exonic regions and the 3'UTR of sixteen genes related to the vitamin D pathway and the high-affinity IgE receptor, namely, FCER1A, MS4A2,

SUBMITTER: Amo G 

PROVIDER: S-EPMC12528179 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature