Challenging or less challenging oral diadochokinetic tasks-what works best in Huntington disease? A cross-sectional study.

ABSTRACT:

Background

In Huntington disease (HD), speech alterations are common and may emerge before onset of chorea. Slow and irregular motion rates, i.e. altered oral diadochokinesis (oDDK), are a distinctive feature. This study investigated oDDK using alternating (AMR) and sequential motion rate (SMR) tasks in manifest HD and explored the impact of antidopaminergic medications (ADM).

Methods

Speech samples were acquired from 30 healthy controls (14 men; 27-78 years¸ age- and gender-matched to HD subjects) and 35 individuals with early-to-moderate HD (18 men; 22-76 years) phenotyped using standardized scales (UHDRS'99) and MR imaging to estimate disease severity. Acoustic analysis was used to quantify rate and regularity of oDDK. In an exploratory subgroup analysis, the impact of AD

SUBMITTER: Hannemann W 

PROVIDER: S-EPMC12528184 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature