The association between muscle mass and change in physical functioning in older adults: a systematic review and meta-analysis of prospective studies.

ABSTRACT:

Purpose

The aim of this review is to investigate the prospective association between muscle mass and physical functioning in older adults, and to explore sources of variability in this association.

Methods

Three databases were searched for prospective, observational studies investigating any assessment of muscle mass and functional decline in older adults (mean age 65 + years). 72 studies were included. Meta-analyses using results of the most adjusted statistical models were performed using Review Manager version 5.3.5.

Results

Most studies were conducted in the community setting (n = 64) and used incident ADL limitations/disability as outcome (n = 44). Across studies, 6 body composition methods and 34 different parameters of muscle mass were used, including ratios. A

SUBMITTER: Visser M 

PROVIDER: S-EPMC12528211 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature