Comparable area under the curve for three risk scores to detect interstitial lung disease in patients with rheumatoid arthritis: an external validation.

ABSTRACT: Rheumatoid Arthritis associated Interstitial Lung Disease (RA-ILD) is an extraarticular manifestation of rheumatoid arthritis (RA) associated with increased morbidity and mortality. Several risk factors for RA-ILD have been identified, one is the promotor variant of mucin 5 B gene (MUC5B). Juge et al., Wheeler et al. and Koduri et al. have developed risk scores for identifying patients with RA at risk of RA-ILD. We aimed to externally validate the three risk scores and further investigate the frequency of MUC5B promotor variant and its association with subclinical lung changes in patients with RA in northern Sweden. Our cohort consisted of 54 patients with RA. The risk score variables were evaluated in binary logistic regression and validated using area under the receiver operating charact

SUBMITTER: Blomberg E 

PROVIDER: S-EPMC12528251 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature