Coffee intake, genetic variants, and chronic kidney disease: a cross-sectional analysis of the Japan Multi-Institutional Collaborative Cohort (J-MICC) study.

ABSTRACT:

Purpose

The present study aimed to clarify associations between coffee intake and kidney function with consideration of the effect modifications from coffee intake-related genetic polymorphisms.

Methods

This cross-sectional study included 7,468 Japanese participants 35-69 years old (3,953 women: 52.9%) from the baseline survey of the Japan Multi-Institutional Collaborative Cohort study. Coffee intake was estimated with a self-administered questionnaire. Three coffee intake-related single nucleotide polymorphisms (in AHR [rs4410790], HECTD4 [rs2074356], and CYP1A2 [rs762551]) were selected with reference to previous studies. Estimated glomerular filtration rate (eGFR [ml/min/1.73 m²]) and CKD (defined as eGFR < 60 ml/min/1.73 m²) were determined.

Resu

SUBMITTER: Unohara T 

PROVIDER: S-EPMC12528254 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature