Cortical thinning and white matter alterations in myotonic dystrophy type 2 over a 10-year period.

ABSTRACT:

Background

Cortical thinning and microstructural white matter alterations have been shown to occur in myotonic dystrophy type 2 (DM2). So far, longitudinal investigations are scarce and no significant differences of changes over 5 years were found between patients and healthy controls (HC). We hypothesized that DM2 might develop stronger brain alterations after long time periods of 10 years and that cortical thickness might be a representative biomarker for tracking cerebral changes in DM2.

Methods

Ten DM2 patients and seven HC were included in this study who received two brain MRI examinations over 10 years. Brain images were segmented to obtain cortical thickness (CT) by use of CAT12. CT alterations were investigated with surface-based morphometry in CAT12. Diffusion tenso

SUBMITTER: Krieger B 

PROVIDER: S-EPMC12528299 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature