Efficacy of Intra-arterial [¹⁷⁷Lu]Lu-DOTATATE monotherapy for treatment-refractory meningioma.

ABSTRACT:

Purpose

For meningiomas that are refractory after local treatments, there are no systemic evidence-based therapeutic options to date. In recent years, somatostatin-targeted radionuclide therapy has emerged as a promising new treatment modality. Recent studies have indicated that intra-arterial administration of [¹⁷⁷Lu]Lu-DOTATATE may increase the tumor absorbed dose. This study aims to assess the efficacy of intra-arterial [¹⁷⁷Lu]Lu-DOTATATE in a cohort of treatment-refractory meningiomas.

Materials and methods

Retrospective cohort study including patients diagnosed with treatment-refractory meningioma (WHO grade 1-3), who had received at least one cycle of intra-arterial [¹⁷⁷Lu]Lu-DOTATATE. Primary outcomes were progression-free survival (PF

SUBMITTER: El Ghalbouni A 

PROVIDER: S-EPMC12528330 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature