Role of Neo-Sinus on Thrombogenicity of Aortic Valve Prostheses: Experimental Proof-of-Concept Study.

ABSTRACT:

Purpose

Transcatheter aortic valve replacement (TAVR) is the standard treatment for patients with aortic diseases at high surgical risk. Transcatheter heart valve prostheses (THV) are inserted into the aortic valve, creating a new area between the native and artificial leaflets. This area, known as neo-sinus, increases the thrombogenicity of THVs. But there is a lack of testing methods that evaluate thrombogenicity in vitro.

Methods

To analyze the flow field within the native sinus and the neo-sinus, Particle Image Velocimetry (PIV) was performed with a thrombosis tester. Additionally, a comparative study was conducted with porcine blood on two polycarbonate urethane valves, with and without neo-sinus, respectively. Blood samples collected every hour were analyzed for platel

SUBMITTER: Thoenissen S 

PROVIDER: S-EPMC12528357 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature