Bioinformatics analysis of the expression of TRIM31 mRNA and protein in pan-cancer tissues and their prognostic relevance.

ABSTRACT: TRIM31 is a member of the tripartite motif (TRIM) protein family. However, its precise expression pattern and functional role in diverse cancer types remain unclear. This study aimed to analyze the role and clinical significance of TRIM31 in pan-cancer and gastric cancer (GC). We investigated the relationships between TRIM31 expression and multiple aspects, including immune infiltration, stemness index, and responses to chemotherapy and immunotherapy, and examined the association between TRIM31 expression and the prognosis of patients with GC. TRIM31 expression was elevated in most tumors. Further scrutiny revealed an association between TRIM31 expression and multiple tumor characteristics. Increased TRIM31 expression reduced the benefits of immunotherapy, which were positively correlated

SUBMITTER: Mei Y 

PROVIDER: S-EPMC12528411 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature