Nasal immunization with Streptococcus mutans membrane vesicles and eggshell-derived hydroxyapatites elicits enhanced antigen-specific mucosal IgA responses.

ABSTRACT: Nasal vaccines characterized by secretory IgA (SIgA) induction are effective in preventing mucosal infection. SIgA induction is potentiated by mucosal adjuvants, and the exploration of new safe and effective candidates is important. Nanosized hydroxyapatites (HAs) have the potential to enhance immune responses. The membrane vesicles (MVs) released from Streptococcus mutans UA159, a cariogenic bacterium, contain immunogenic glucosyltransferases (GTFs). We evaluated HAs made from eggshell waste, including nanosized particles, as a mucosal adjuvant against nasally administered MVs. Scanning electron microscopy revealed that the MVs were adsorbed to the eggshell-derived HA surface, and these complexes formed various sizes of aggregates. The coadministration of eggshell-derived HAs reinforced t

SUBMITTER: Hashizume-Takizawa T 

PROVIDER: S-EPMC12528493 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature