Standardization of postmortem human brainstem along the rostrocaudal axis to accommodate for inter-specimen structural heterogeneity.

ABSTRACT: There is increasing recognition of the critical need for postmortem studies of human brainstem tissues for elucidating the pathophysiology of neurological disorders. While the brainstem is critical for a myriad of functions it is relatively small with a complex organization of tracts and nuclei. So, interindividual heterogeneity in brainstem structure that can derive from tissue procurement or be related to anthropometric features like height or weight can greatly impact studies of brainstem structure and function. In the absence of explicit approaches to account for these sources of heterogeneity drawing inferences from interindividual comparisons can be challenging. This study used postmortem brainstem samples from well-characterized older decedents to systematically assess factors contr

SUBMITTER: Celada M 

PROVIDER: S-EPMC12528497 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature