Combined mechanical ventilatory and mechanical circulatory support aids pulmonary vascular state in cardiogenic shock.

ABSTRACT:

Background

Percutaneous ventricular assist devices (pVADs) support patients in circulatory failure and increasingly concomitant respiratory failure. The presence of co-existent lung disease creates a management challenge due to cardiopulmonary interactions, especially when there is simultaneous mechanical ventilation and mechanical circulatory support. Enhanced understanding of the combined effects of these devices is necessary to better inform care for circulatory failure patients.

Methods

A porcine model of titratable acute cardiogenic shock was used to quantify the effect of pVAD support on cardiac loading states in five intubated animals with positive pressure ventilation and varied intrathoracic pressure. Cardiovascular hemodynamics were assessed across positive end-exp

SUBMITTER: Lamberti KK 

PROVIDER: S-EPMC12528517 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature