Tuina Alleviates Anxiety-Like Behaviors Associated With Neuropathic Pain Through the Modulation of Synaptic Plasticity in the Anterior Cingulate Cortex.

ABSTRACT:

Background

As the disease progresses, neuropathic pain (NP) is often accompanied by anxiety-like behaviors, which are associated with plastic changes in the synaptic structure and function within the anterior cingulate cortex (ACC). Tuina is a traditional Chinese manual therapy. This study aims to investigate the effects of Tuina on pain behaviors and related anxiety-like behaviors in rats with the chronic constriction injury (CCI) model, as well as its impact on synaptic plasticity in the ACC.

Methods

The rats were randomly divided into three groups: Sham, CCI, and Tuina. An NP comorbid anxiety model was established by inducing CCI in the right sciatic nerve. The pain-related behaviors and anxiety-like behaviors in rats were assessed using the mechanical withdrawal threshol

SUBMITTER: Na R 

PROVIDER: S-EPMC12528543 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature