Sex-difference in the association between Triglyceride-Glucose (TyG) index and dementia.

ABSTRACT:

Purpose

This study aims to evaluate the association between the insulin resistance as assessed by Triglyceride-Glucose (TyG) index and dementia and to determine whether this relationship varies by sex.

Methods

We assessed TyG index in older patients admitted to an Italian Memory Clinic with different cognitive status: 335 (71% females-F) participants with Alzheimer's disease (AD), 99 (61% F) with vascular dementia (VAD), 301 (67% F) with mixed dementia (MIXED: AD + VAD), 442 (57% F) with mild cognitive impairment (MCI), and 173 cognitively healthy controls (61% F).

Results

We found that only in females high TyG index was associated with a greater probability of receiving a diagnosis of MCI (odd ratio - O.R.: 1.91, 95% confidence interval - C.I.: 1.08-3.34), VAD (O.R.:

SUBMITTER: Zuliani G 

PROVIDER: S-EPMC12528581 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature