Development of an ADME gene signature for prognostic and therapeutic stratification in gastric cancer.

ABSTRACT: A pivotal determinant of tumor therapy efficacy lies in the absorption, distribution, metabolism, and excretion (ADME) processes that govern drug disposition within the body. We intended to establish a prognostic model incorporating ADME-related genes to forecast the survival rate and therapeutic response in gastric cancer (GC) patients. By integrating Cox regression and LASSO analysis for dimensionality reduction and feature selection, we identified a stable five-gene signature with significant prognostic value. Subsequently, the stability of the model was verified. A nomogram incorporating these genes was constructed and integrated with a clinicopathological feature prediction system to improve its clinical applicability. The results revealed a robust correlation between ADME-related gen

SUBMITTER: Wang D 

PROVIDER: S-EPMC12528583 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature