Neutrophil extracellular traps (NETs)-score: a novel prognostic marker for colorectal cancer patients.

ABSTRACT:

Background

Colorectal cancer (CRC) ranks as the third most prevalent cancer globally, displaying significant tendencies towards recurrence and metastasis. Advanced CRC typically necessitates systemic treatments such as chemotherapy, targeted therapy, and immunotherapy, yet the development of primary and acquired drug resistance remains a significant challenge. Neutrophil extracellular traps (NETs) represent a complex network structure comprising DNA, histones, and antimicrobial peptides generated by activated neutrophils, which have been implicated in promoting cancer progression. However, the precise mechanisms underlying the interaction between NETs-related gene signatures and cancer cells remain poorly understood.

Methods

The gene expression profile of TCGA-CRC was obtain

SUBMITTER: Wu XL 

PROVIDER: S-EPMC12528602 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature