Inhibition of NR2F2 suppresses invasion ability and modulates EMT marker in head and neck squamous cell carcinoma.

ABSTRACT: The nuclear receptor subfamily 2 group F member 2 (NR2F2) has emerged as a potential therapeutic target in cancer due to its involvement in tumor progression, metastasis, angiogenesis, and epithelial-mesenchymal transition (EMT). However, its precise role in head and neck squamous cell carcinoma (HNSCC) and other cancer types remains to be elucidated. To investigate the role of NR2F2 in HNSCC, we examined its expression in relation to lymph node metastasis (LNM) in patient samples. Further functional studies were conducted using knockdown experiments and NR2F2 inhibitors, COUP-TFII inhibitor A(CIA) and 4-methoxynaphthalene-1-ol(4-MNol), in HNSCC cell lines. Invasion and migration assays were performed to assess the impact of NR2F2 modulation. Additionally, Western blot analysis was conduct

SUBMITTER: Noh JK 

PROVIDER: S-EPMC12528631 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature