Functional characterization of key enzymes involved in the biosynthesis of distinctive flavonoids and stilbenoids in <i>Morus notabilis</i>.

ABSTRACT: The mulberry (Morus notabilis) is a medicinal and edible plant and contains diverse flavonoids and stilbenoids with significant medicinal benefits. The biosynthesis of these compounds has only been partially elucidated. In the present investigation, we identified and characterized two 4-coumarate: coenzyme A ligases (Mn4CL1 and Mn4CL2), two polyketide synthases (MnCHS and MnSTS), three chalcone reductases (MnCHR1-3), and two 2-oxoglutarate-dependent dioxygenases (MnFLS and MnF3H) involved in flavonoids and stilbenoid biosynthesis. MnCHS converts p-coumaroyl-CoA into naringenin and facilitates the novel conversion of 2,4-dihydroxycinnamoyl-CoA to steppogenin, which features hydroxyl groups at the 4' and 6' positions on the B ring. MnSTS could convert p-coumaroyl-CoA and

SUBMITTER: Hu MW 

PROVIDER: S-EPMC12528653 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature