In vitro comparison of the susceptibilities of the same drug resistance mutations to reverse-transcriptase inhibitors of subtype B and CRF01_AE HIV-1 strains.

ABSTRACT: As the recommended drugs for first-line regimens in HIV-1 infections, reverse-transcriptase inhibitors (RTIs) are widely used around the world. To escape from the selective pressure imposed by RTIs, HIV-1 constantly mutates to adapt to its environment. However, it is unclear how resistance mutations emerging in response to RTIs affect drug susceptibility in strains of different subtypes. To explored this phenomenon, typical RTI-induced drug resistance mutations (DRMs) were selected to test their effects on the susceptibility of different subtype strains. The same RTI-induced DRMs were introduced into infectious clones of subtypes B and CRF01_AE, and phenotypic resistance tests were performed to compare the differences in susceptibilities to various RTIs. The experimental results revealed t

SUBMITTER: Li H 

PROVIDER: S-EPMC12528743 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature