Constructing a Model Using Clock-Related lncRNAs for Predicting the Tumor Microenvironment of Gliomas.

ABSTRACT:

Purpose

Circadian locomotor output cycles kaput (CLOCK) and its related genes play important roles in cellular functions. This study aims to construct a predictive model for CLOCK-related genes and identify lncRNAs that may influence Tumor Microenvironment of Glioma.

Method

We included bulk RNA-sequencing data and clinical information for glioma samples from the TCGA and CGGA databases. Univariate Cox and LASSO-Cox analyses were used to screen CLOCK-related genes. Consensus clustering was applied to classify glioma samples, followed by differential gene expression analysis. CLOCK-related lncRNAs were identified through correlation analyses, hub lncRNAs were selected using LASSO-Cox, and their expression was validated by qPCR in cultured glioma cell lines.

Finding

We i

SUBMITTER: Gong M 

PROVIDER: S-EPMC12528804 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature