Causal Relationship Between Anxiety Disorders and Cancers: A Bidirectional Two-Sample Mendelian Randomization Study.

ABSTRACT:

Background

Anxiety disorders are common psychiatric problems that often accompany cancer. The aim of this study was to investigate the potential causal relationship between anxiety disorders and common cancers.

Methods

We utilized publicly available summary statistics from large-scale genome-wide association studies, selecting genetic variant loci associated with anxiety disorders and common cancers as instrumental variables (IVs). These IVs underwent quality control according to three underlying assumptions. The results of the Mendelian randomization (MR) study were analyzed using the inverse variance weighted (IVW) method, along with MR-Egger regression and weighted median estimation (WME) methods, to evaluate the bidirectional causal relationship between anxiety disorders

SUBMITTER: Su J 

PROVIDER: S-EPMC12528808 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature