Optimization of Spinal Cord Perfusion Pressure for Improvement of Neurological Outcome in Traumatic Spinal Cord Injury: A Systematic Review and Meta-Analysis.

ABSTRACT: The optimal hemodynamic management of traumatic spinal cord injury (tSCI) is not well established. We performed a systematic review and meta-analysis of patients with acute tSCI to assess the role of lumbar cerebrospinal fluid drainage (CSFD) and to identify factors predictive of neurological improvement. Three studies involving 46 patients with acute tSCI, lumbar drain placement with CSFD, and available pre- and post-intervention American Spinal Injury Association (ASIA) Impairment Scale or International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) motor scores were identified. One study was analyzed separately (Cohort A) using ASIA grade because post-intervention ISNCSCI motor scores were not reported. In the remaining two studies (Cohort B), two independent

SUBMITTER: Hovis GEA 

PROVIDER: S-EPMC12528847 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature