Exploring the Impact of Obesity on Progression and Prognosis in Early-Stage Endometrioid Endometrial Carcinoma.

ABSTRACT:

Background

Endometrioid endometrial carcinoma (EEC) is the most prevalent malignancy affecting the female reproductive system, and obesity is a significant risk factor. In this study, we examined the influence of saturated fatty acids (SFAs) on early-stage EEC progression.

Methods

A two-sample Mendelian randomization (MR) analysis using single-nucleotide polymorphisms as instrumental variables was used to assess the potential causal associations among body mass index (BMI), the main components of adipose tissue, and EEC. Clinical data from 231 patients with EEC at Benxi Central Hospital were analyzed according to BMI categories. CCK-8, apoptosis, cell cycle, scratch, and transwell assays were used to examine the biological behavior of Ishikawa cells treated with palmitic aci

SUBMITTER: Wang J 

PROVIDER: S-EPMC12528850 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature