Sex Dimorphism Influences Cortical Microglial Morphological and Phenotypic Marker Profile after Closed Head Mild Traumatic Brain Injury in Rats.

ABSTRACT: Neuroinflammation is a nearly ubiquitous secondary injury process after traumatic brain injury (TBI) involving microglia. The time course of microglial functional transition between pro-inflammatory and anti-inflammatory states after mild TBI (mTBI) and the potential influence of sex in microglial response is not well-understood. To investigate interactions between sex and microglial activation states in the subacute post-mTBI period, we performed a morphological and phenotypic marker analysis on cells from male and female rats following closed head single impact (smTBI), repetitive impacts (rmTBI), or sham conditions at 24 h, 72 h, or 1 week postinjury. There was a significant increase in microglia population 24 h post-smTBI and at all time points for rmTBI in both male and female cells.

SUBMITTER: Datta Roy PM 

PROVIDER: S-EPMC12528851 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature