The exercise-conditioned human serum and skeletal muscle cells secretome induce apoptosis in breast cancer cells.

ABSTRACT:

Background

Regular exercise training provides significant health benefits among cancer survivors and is associated with lower breast cancer mortality and reduced risk of recurrence. Both exercise-induced factors secreted into circulation (exerkines) and bioactive molecules contained in skeletal muscle secretome have been proposed to affect the tumor microenvironment and mediate some of the anti-carcinogenic effects of exercise. This study utilized exercise-conditioned human serum obtained from breast cancer patients during chemotherapy and skeletal myotubes' secretome after mechanical loading to investigate their effects on breast cancer cells in vitro.

Methods

Breast cancer patients participated in a 12-week exercise training program during their chemotherapy, and blood ser

SUBMITTER: Papadopetraki A 

PROVIDER: S-EPMC12528907 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature