Beyond Life's Essential 8: optimizing cardiovascular health metrics to predict mortality.

ABSTRACT:

Background

Cardiovascular health (CVH), as assessed by the American Heart Association's Life's Essential 8 (LE8), is strongly associated with mortality risk. However, whether rescoring or weighting individual CVH components improves mortality prediction remains unclear.

Methods

Using data from the 2005-2018 National Health and Nutrition Examination Survey, we examined the associations between CVH categories and risks of all-cause and cardiovascular disease (CVD) mortality. We compared three CVH scoring approaches: the original LE8 model, a rescored model with recalibrated eight metrics, and a weighted model assigning relative importance to each metric. Cox proportional hazards models adjusted for confounders estimated hazard ratios. Model performance was evaluated by C-stati

SUBMITTER: Peng Y 

PROVIDER: S-EPMC12528943 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature