High-resolution structural connectivity mediates age-related differences in functional connectivity and fluid cognition.

ABSTRACT: Magnetic resonance imaging studies using diffusion-weighted imaging suggest that age-related cognitive decline and alterations in brain function, in healthy adults, are at least partly explained by the degradation of white matter pathways connecting distributed brain regions. Studies of younger adults and animal models suggest that more precise estimates of white matter connectivity may be achieved by higher resolution, relative to standard spatial resolution, diffusion-weighted imaging. Here, in a cross-sectional study of healthy adults across the lifespan (n = 140; ages 18-88 years; 72 females), we compared age-related differences in measures of white matter structural connectivity from standard (1.5 mm³ voxels; 3.375 µl volume) and high-resolution (1 mm³; 1

SUBMITTER: Merenstein JL 

PROVIDER: S-EPMC12528985 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature