Safety evaluation of the food enzyme cellulase from the non-genetically modified <i>Aspergillus niger</i> strain AC 4-984.

ABSTRACT: The food enzyme cellulase (4-(1,3;1,4)-β-d-glucan 4-glucanohydrolase; EC 3.2.1.4) is produced with the non-genetically modified Aspergillus niger strain AC 4-984 by Shin Nihon Chemical Co., Ltd. The food enzyme was considered free from viable cells of the production organism. The food enzyme is intended to be used in ten food manufacturing processes. Since residual amounts of food enzyme-total organic solids (TOS) are removed in two processes, dietary exposure was calculated for the remaining eight food manufacturing processes. It was estimated to be up to 0.993 mg TOS/kg body weight (bw) per day in European populations. Genotoxicity tests did not indicate a safety concern. The systemic toxicity was assessed by means of a repeated dose 90-day oral toxicity study in rats. The Panel i

SUBMITTER: EFSA Panel on Food Enzymes (FEZ) 

PROVIDER: S-EPMC12528999 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature