Decline in Complications and Mortality in Chronic Liver Disease and Cirrhosis: A Population-Based Cohort Study From Northeastern Italy.

ABSTRACT:

Background

Current trends in complications and mortality among individuals with chronic liver disease and cirrhosis are largely unknown.

Objective

To explore changes in mortality trends among patients with cirrhosis and chronic liver disease based on etiology in the Veneto Region (Italy), to differentiate mortality between liver-related and non-liver-related causes before and during the COVID-19 pandemic, and to determine trends in the development of cirrhosis complications.

Methods

Three subsequent population-based cohorts of individuals with chronic liver disease/cirrhosis were identified in Veneto (North-eastern Italy, 4.9 million residents): the first enrolled before introduction of direct-acting antivirals (DAA); the second corresponding to full availability of D

SUBMITTER: Russo FP 

PROVIDER: S-EPMC12529006 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature