Poloxamer-based thermosensitive injectable hydrogels containing a self-assembling peptide for <i>In situ</i> gelation.

ABSTRACT: This study presents the development and characterization of a novel thermosensitive injectable hydrogel designed to enhance the biomechanical properties of poloxamer 407 (P407) through the incorporation of a self-assembling peptide. The primary objective was to engineer a formulation that rapidly gels following intra-articular (i.a.) injection, exhibits improved mechanical strength, and enables sustained release of embedded therapeutic cargo. Gelation time assays demonstrated that the P407-peptide formulation solidified more quickly than P407 alone at equivalent concentrations. Rheological analysis revealed a 1.5 kPa increase in storage modulus in the hybrid hydrogel, confirming improved mechanical integrity. In vitro biocompatibility was assessed using human chondrocyte cell line,

SUBMITTER: Sayedipour SS 

PROVIDER: S-EPMC12529111 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature