LCI Engineering for Improved Polystyrene Binding: The Impact of Aromatic Amino Acid Substitutions.

ABSTRACT: Polystyrene (PS) is a widely used synthetic polymer with applications in biosensing, medical devices, and packaging. PS often requires surface modifications to enhance biocompatibility, adhesion, and chemical functionality. Material-binding peptides (MBPs) provide a biobased and scalable approach for PS functionalization. Therefore, optimizing their binding properties can ensure stable and efficient binding under industrial application conditions. In this study, we systematically explored how aromatic amino acid substitutions (His, Phe, Trp, and Tyr) affect the PS binding ability of the MBP named liquid chromatography peak I (LCI). A total of 178 aromatic amino acid substitutions were evaluated across all 47 positions of LCI, resulting in the identification of 56 substitutions across 32 po

SUBMITTER: Singab RA 

PROVIDER: S-EPMC12529122 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature