Hierarchical Micro-Nano Surface Roughness Wax-Impregnated Cotton Fabrics Platform for Cell-Based Diagnostics.

ABSTRACT: The hierarchical micronano structured surface plays a significant role in influencing cell behavior, making it a critical feature for biomaterials. Increased surface roughness, such as that achieved with wax-impregnated cotton fabrics, mimics the 3D native environment of fibroblasts, offering a novel approach for cell-based diagnostics. Traditional biopsy methods are often time-consuming and complex. To address this, we developed a novel point-of-care diagnostic platform utilizing wax-impregnated cotton fabrics with varying melting points, resulting in a rough hierarchical surface conducive to cell attachment. The platform's performance was evaluated based on physical properties (surface characteristics and adhesion), cell growth profiles, attachment morphology, and cell staining ability u

SUBMITTER: Wahab NM 

PROVIDER: S-EPMC12529141 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature