First Step into Praziquantel Raw Material Color Change Investigation: The Role of Thermal, Spectroscopic, and Microscopic Techniques.

ABSTRACT: Praziquantel (PZQ) is an anthelmintic agent used worldwide for the treatment of schistosomiasis. PZQ is used as a racemate, and it is practically insoluble in water. The PZQ racemate is a white to nearly white crystalline powder, and few studies showed a color change from white to pink. However, no special attention has been given to this matter. The present study aimed at a comprehensive understanding of PZQ change in color because a significant impact on its dissolution was observed. We discuss a series of analytical techniques, and we emphasize the importance of understanding solid state properties together with the conventional quality control evaluation. Two batches of PZQ raw material with different colors (white and light pink) were used. The dissolution profiles of the samples and

SUBMITTER: Prado LD 

PROVIDER: S-EPMC12529163 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature