Water-Soluble NNN-Type Pincer Ligand and Its Platinum, Copper, and Cobalt Complexes: Synthesis, Characterization, Biological Activity, and Computational Docking Study.

ABSTRACT: This study successfully synthesized and characterized a novel bis-(pyridylimino)-isoindole ligand, 4-(((1Z,3Z)-1,3-bis-((4-methylpyridin-2-yl)-imino)-isoindolin-5-yl)-oxy)-5-(1,2-dihydroxyethyl)-tetrahydro-furan-2,3-diol and its platinum-(II), copper-(II), and cobalt-(II) complexes. Many biological properties of these compounds (1b-4b) such as antioxidant, DNA cleavage, antimicrobial, microbial cell viability inhibition, biofilm inhibition, and antidiabetic activity were also investigated. Compounds 2b, 3b, and 4b exhibited 100% free radical scavenging activity equivalent to Trolox and ascorbic acid used as standards at a 200 mg/L concentration. All compounds showed powerful DNA nuclease activity at 50 mg/L concentrations. The most efficient MIC values of

SUBMITTER: Ozcesmeci M 

PROVIDER: S-EPMC12529181 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature