Visible-Light-Driven Photocatalyst-Free Multicomponent Reactions: Green Synthesis of Tetraketones as Potent Antiviral Agents through Virtual Screening, Molecular Docking, and MD Simulations.

ABSTRACT: Herein, we report a photocatalyst (PC)-free, visible-light (30 W LED)-driven green and sustainable synthesis of a series of functionalized tetraketones by a one-pot multicomponent reaction at room temperature. The ethanol-mediated reaction of variably substituted aromatic/heteroaromatic, aliphatic aldehydes, and dimedone furnished the biologically relevant tetraketones in very good yields (72-92%) in 10 min to 5 h. The key advantages of the current process include its environmentally benign aspect, operational simplicity, easy isolation of the products, high yields, PC- and metal-free aspects, employment of visible light as a green and sustainable energy source, and gram-scale synthesis. The synthesized tetraketones are further subjected to in silico studies which investigate the po

SUBMITTER: Acharya SS 

PROVIDER: S-EPMC12529182 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature