Glucose-Lowering Medication Classes and Cardiovascular Outcomes in Patients With Type 2 Diabetes.

ABSTRACT:

Importance

Major adverse cardiovascular events (MACEs) are primary causes of morbidity and mortality in adults with type 2 diabetes (T2D), yet few head-to-head randomized trials have compared the effects of glucose-lowering medications on MACEs, and most observational analyses are limited by inadequate bias adjustment methods.

Objective

To compare the effectiveness of sustained exposure to 4 classes of glucose-lowering medications (sulfonylureas, dipeptidyl peptidase-4 inhibitors [DPP4is], sodium-glucose cotransporter-2 inhibitors [SGLT2is], and glucagon-like peptide-1 receptor agonists [GLP-1RAs]) on MACEs in US adults with T2D using modern causal methods combined with machine learning.

Design, setting, and participants

This comparative effectiveness study included a

SUBMITTER: Neugebauer R 

PROVIDER: S-EPMC12529185 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature