Zinc-integrated PLGA/chitosan nanofiber mesh: a platform for wound healing applications.

ABSTRACT: Non-healing wounds present significant challenges to patients and healthcare systems, often causing infections and chronic pain due to impaired self-regeneration. Zinc (Zn) shows promise in biomedical applications, particularly wound healing, as its degradation releases Zn²⁺ ions that enhance cell proliferation, angiogenesis, and antimicrobial activity. These properties make Zn ideal for bioresorbable wound dressings, scaffolds, and tissue repair coatings. This study aimed to incorporate metallic Zn particles into electrospun nanofiber meshes of poly(d,l-lactic-co-glycolic acid) (PLGA) and PLGA/chitosan (PLGA-CH) and evaluate their wound healing potential. We electrospun polymer-Zn nanoparticle mixtures to fabricate composite fibrous meshes. We assessed Zn's impact on sca

SUBMITTER: Davies D 

PROVIDER: S-EPMC12529250 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature