Rare mutations at EGFR L747 position: molecular characteristics and superior response to afatinib in NSCLC patients.

ABSTRACT:

Background

Little is known about the molecular characteristics and responses to different therapies in missense mutations at epidermal growth factor receptor (EGFR) L747 position (EGFR L747X) due to their low prevalence and frequent misidentification by routine PCR kit. We aimed to investigate the molecular features through next-generation sequencing (NGS) and responses in lung cancer patients with EGFR L747X.

Patients and methods

The distribution and molecular characteristics of EGFR L747X mutations were analyzed through NGS tests carried out in 41 369 lung cancer patients. Ba/F3 cells expressing EGFR L747P, L747S and L747V were established to evaluate the sensitivity to different EGFR tyrosine kinase inhibitors (TKIs). Binding affinity was predicted through structural mode

SUBMITTER: Huang Y 

PROVIDER: S-EPMC12529304 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature