Exploring the impact of NGS on diagnostics and treatment of sarcoma: insights from real-world data across multiple institutions in Europe.

ABSTRACT:

Background

Sarcomas comprise a heterogeneous group of malignant tumors of mesenchymal origin where diagnosis plays a crucial role in tailoring disease management and treatment. In this context, there is a lack of data assessing the potential benefit of next-generation sequencing (NGS) reflecting real-world scenarios across different countries. The aim of our analysis includes both the diagnostic refinement and the therapeutic guidance with the use of NGS in sarcoma treatment strategy.

Materials and methods

We retrospectively analyzed 694 samples from six sarcoma-expert institutions from three countries in Europe: Greece, Poland, and Spain, thus reflecting a variety of scenarios.

Results

We identified 90 different sarcoma histological subtypes, of which the most common

SUBMITTER: Kyriazoglou A 

PROVIDER: S-EPMC12529307 | biostudies-literature | 2025 Sep

REPOSITORIES: biostudies-literature