(Es)ketamine as a treatment for depressive episodes with psychotic features: systematic review.

ABSTRACT:

Background

Psychotic symptoms in depression are linked to worse outcomes, and treatment options are limited. Ketamine and esketamine are effective antidepressants, yet most studies have excluded patients with a history of psychotic symptoms.

Aims

To evaluate by systematic review the efficacy and safety of ketamine and esketamine in treating patients with unipolar or bipolar depressive episodes with psychotic features.

Method

A comprehensive search of the PubMed, Ovid and Web of Science databases was conducted up to 2 November 2023. We included any study that reported the use of ketamine or esketamine in patients with depressive episodes with psychotic symptoms. The primary outcomes assessed were variations in depressive and psychotic symptoms and the incidence of adve

SUBMITTER: Santos HC 

PROVIDER: S-EPMC12529312 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature