Aging-dependent immunological changes in multiple sclerosis.

ABSTRACT: Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease in which immune dysregulation plays a central role. As the life expectancy of people with MS (pwMS) increases, understanding how aging affects their immune system-collectively referred to as immunosenescence-has become crucial. In this study, we characterized immunosenescence in pwMS by analyzing age-related changes in the immune system. To fulfill this, blood samples were collected from pwMS and healthy controls (HCs) of independent cohorts: i) immune cell populations were assessed in PBMCs (n= 110), ii) thymic involution and telomere attrition were measured in DNA samples (n=150), and iii) inflammatory and neurodegeneration markers were evaluated in plasma (n=146).Our results revealed distinct age-associated

SUBMITTER: Iribarren-Lopez A 

PROVIDER: S-EPMC12529361 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature